Airway Mucin Secretion
نویسندگان
چکیده
منابع مشابه
Regulated Mucin Secretion from Airway Epithelial Cells
Secretory epithelial cells of the proximal airways synthesize and secrete gel-forming polymeric mucins. The secreted mucins adsorb water to form mucus that is propelled by neighboring ciliated cells, providing a mobile barrier which removes inhaled particles and pathogens from the lungs. Several features of the intracellular trafficking of mucins make the airway secretory cell an interesting co...
متن کاملAirway goblet cell mucin: its structure and regulation of secretion.
Mucociliary clearance is a major function of the airway epithelium. This important function depends both on the physicochemical properties of the airway mucus and on the activity of the cilia. The former, in turn, is dependent mainly on the quality and quantity of mucous glycoproteins or mucins, which are produced by two different cell types, namely, goblet cells of the epithelium and mucous ce...
متن کاملThe Secretion of Gastric Mucin
The protective and lubricative r6le of mucus in the gastro-intestinal tract has been reported and studied by many investigators (Claude Bernard (4), Schiff (18), de Klug (12), Whitlow (19), Elliott (7), Pavlov (16), Berg and Jobling (3), Leriche (14), and Bucher (6)). An absolute or relative deficiency of gastric mucus has been frequently suggested as a possible etiologic factor in gastro-duode...
متن کاملEffect of anion secretion inhibitors on mucin content of airway submucosal gland ducts.
In porcine bronchi, inhibition of both Cl- and[Formula: see text] transport is required to block the anion secretion response to ACh and to cause mucus accumulation within ACh-treated submucosal gland ducts [S. K. Inglis, M. R. Corboz, A. E. Taylor, and S. T. Ballard. Am. J. Physiol. 272 ( Lung Cell. Mol. Physiol. 16): L372-L377, 1997]. In this previous study, a combination of three potential [...
متن کاملCalcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are hallmark features of inflammatory airway diseases, including asthma. Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM. The epithelial expression is increased in asthmatics, particularly in secretory cells. Based on...
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ژورنال
عنوان ژورنال: Annals of the American Thoracic Society
سال: 2018
ISSN: 2329-6933,2325-6621
DOI: 10.1513/annalsats.201806-371aw